Journal of Orthopaedic Nursing
Volume 13, Issue 4 , Pages 165-171 , November 2009

New oral anticoagulants to revolutionise venous thromboembolism (VTE) management

  • Ricky Autar, PhD, MSc, BA (Hons), DipN (Principal Lecturer)

      Affiliations

    • Corresponding Author InformationTel.: +44 0116 2013945.

References 

  1. Autar. R., 2002. Advancing Clinical Practice in the Management of Deep Vein Thrombosis (DVT). The Autar DVT Scale Revalidated. PhD thesis. DeMontfort University, Leicester.
  2. Autar R. The management of deep vein thrombosis: the Autar DVT risk assessment scale revisited. Journal of Orthopaedic Nursing. 2003;7:114–124
  3. Blech S, Ebner T, Ludwig-Schwellinger E, et al. The metabolism and disposition of oral direct thrombin inhibitor, dabigatran, in humans. Drug Metabolism and Disposition. 2008;36(2):386–399
  4. Boris LC. New compounds in the management of venous thromboembolism after orthopaedic surgery: focus on rivaroxaban. Vascular Health Risk Management. 2008;4(4):855–862
  5. Colwell CW, Berkowitz SD, Davidson BL, et al. Comparison of ximelagatran, an oral direct thrombin inhibitor with enoxaparin for the prevention of venous thromboembolism following total hip replacement: a randomized, double-blind study. Journal of Thrombosis and Haemostasis. 2003;1:2119–2130
  6. De Nisio M, Middeldorp S, Buller HR. Direct thrombin inhibitors. New England Journal of Medicine. 2005;353(26):2827–2834
  7. Douketis JD, Elkeboom JW, Quinland DJ, et al. Short duration prophylaxis against venous thromboembolism after total hip and knee arthroplasty: a meta-analysis of prospective studies investigating symptomatic outcomes. Archive of Internal Medicine. 2003;162:1465–1471
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  9. Eriksson BL, Dahl OE, Kurth AA, et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. Journal of Thrombosis and Haemostasis. 2007;5:2178–2185
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  17. Hirsh J, O’Donnell M, Eikelboom JW. Beyond Unfractionated heparin and warfarin: current and future advances. Circulation. 2007;216:552–560
  18. Kakkar AK, Brenner B, Dahl OE, et al. Extended duration rivaroxaban versus short term enopxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomized controlled trial. Lancet. 2008;372:31–39
  19. Lassen MR, Ageno W, Borris LC, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. New England Journal of Medicine. 2008;358:2776–2786
  20. Laux V, Perzborn E, Kubitza D, Misselwitz F. Preclinical and clinical characteristics of rivaroxaban: a novel, direct factor Xa inhibitor. Seminar in Thrombosis and Hemostasis. 2007;33(5):515–523
  21. Mueck W, Eriksson BI, Bauer KA, et al. Population pharmacokinetics and pharmacodynamics of rivaroxaban – an oral, direct factor Xa inhibitor in patients undergoing major orthopaedic surgery. Clinical Pharmacokinetics. 2008;47(3):203–216
  22. NICE, 2007. Reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in surgical inpatients. National Institute for Clinical Excellence.
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  24. NICE, 2009. Rivaroxaban for the prevention of venous thromboembolism after total hip or knee replacement in adults. NICE technology appraisal guidance 170. National Institute for Health and Clinical Excellence, London, pp. 1–22.
  25. Perzborn E, Kubitza D, Misselwitz F. Rivaroxaban. A novel, oral, direct factor Xa inhibitor in clinical development for the prevention and treatment of thromboembolic disorders. Hamostaseologie. 2007;4:282–289
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PII: S1361-3111(09)00175-7

doi: 10.1016/j.joon.2009.08.002

Journal of Orthopaedic Nursing
Volume 13, Issue 4 , Pages 165-171 , November 2009